TY - CHAP
T1 - New aspects of oxytocin receptor function revealed by knockout mice
T2 - sociosexual behaviour and control of energy balance
AU - Nishimori, Katsuhiko
AU - Takayanagi, Yuki
AU - Yoshida, Masahide
AU - Kasahara, Yoshiyuki
AU - Young, Larry J.
AU - Kawamata, Masaki
N1 - Funding Information:
We thank T. Onaka (Jichi Medical School, Tochigi, Japan), T. Kimura (Osaka University, Osaka Japan), K. Itoi (Tohoku University, Miyagi, Japan) for collaborations, technical assistance, discussion and encouragement. This work was supported in part by a Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (14360046) and by the Sankyo Foundation of Life Science. M.Y. was supported by a Japan Society for the Promotion of Science Research Fellowship for Young Scientists.
PY - 2008
Y1 - 2008
N2 - To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
AB - To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
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U2 - 10.1016/S0079-6123(08)00408-1
DO - 10.1016/S0079-6123(08)00408-1
M3 - Chapter
C2 - 18655874
AN - SCOPUS:47549116536
SN - 9780444532015
T3 - Progress in Brain Research
SP - 79
EP - 90
BT - Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease
A2 - Neumann, Inga
A2 - Landgraf, Rainer
ER -
