New frontiers in gut nutrient sensor research: Nutrient sensors in the gastrointestinal tract: Modulation of sweet taste sensitivity by leptin

Nao Horio, Masafumi Jyotaki, Ryusuke Yoshida, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

研究成果: Contribution to journalShort survey査読

24 被引用数 (Scopus)

抄録

The ability to perceive sweet compounds is important for animals to detect an external carbohydrate source of calories and has a critical role in the nutritional status of animals. In mice, a subset of sweet-sensitive taste cells possesses leptin receptors. Increase of plasma leptin with increasing internal energy storage in the adipose tissue suppresses sweet taste responses via this receptor. The data from recent studies indicate that leptin may also act as a modulator of sweet taste sensation in humans with a diurnal variation in sweet sensitivity. The plasma leptin level and sweet taste sensitivity are proposed to link with post-ingestive plasma glucose level. This leptin modulation of sweet taste sensitivity may influence an individual's preference, ingestive behavior, and absorption of nutrients, thereby playing important roles in regulation of energy homeostasis.

本文言語英語
ページ(範囲)8-12
ページ数5
ジャーナルJournal of Pharmacological Sciences
112
1
DOI
出版ステータス出版済み - 2010

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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