New frontiers in gut nutrient sensor research: Nutrient sensors in the gastrointestinal tract: Modulation of sweet taste sensitivity by leptin

Nao Horio, Masafumi Jyotaki, Ryusuke Yoshida, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

研究成果: ジャーナルへの寄稿小調査

21 引用 (Scopus)

抄録

The ability to perceive sweet compounds is important for animals to detect an external carbohydrate source of calories and has a critical role in the nutritional status of animals. In mice, a subset of sweet-sensitive taste cells possesses leptin receptors. Increase of plasma leptin with increasing internal energy storage in the adipose tissue suppresses sweet taste responses via this receptor. The data from recent studies indicate that leptin may also act as a modulator of sweet taste sensation in humans with a diurnal variation in sweet sensitivity. The plasma leptin level and sweet taste sensitivity are proposed to link with post-ingestive plasma glucose level. This leptin modulation of sweet taste sensitivity may influence an individual's preference, ingestive behavior, and absorption of nutrients, thereby playing important roles in regulation of energy homeostasis.

元の言語英語
ページ(範囲)8-12
ページ数5
ジャーナルJournal of Pharmacological Sciences
112
発行部数1
DOI
出版物ステータス出版済み - 2 8 2010

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Leptin
Gastrointestinal Tract
Food
Research
Leptin Receptors
Aptitude
Nutritional Status
Adipose Tissue
Homeostasis
Carbohydrates
Glucose

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

New frontiers in gut nutrient sensor research : Nutrient sensors in the gastrointestinal tract: Modulation of sweet taste sensitivity by leptin. / Horio, Nao; Jyotaki, Masafumi; Yoshida, Ryusuke; Sanematsu, Keisuke; Shigemura, Noriatsu; Ninomiya, Yuzo.

:: Journal of Pharmacological Sciences, 巻 112, 番号 1, 08.02.2010, p. 8-12.

研究成果: ジャーナルへの寄稿小調査

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