New Insights into Measles Virus Brain Infections

Shumpei Watanabe, Yuta Shirogane, Yuma Sato, Takao Hashiguchi, Yusuke Yanagi

研究成果: ジャーナルへの寄稿評論記事

4 引用 (Scopus)

抄録

Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases, subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However, the mechanism of MeV propagation in the brain remains unexplained because human neurons affected by the diseases do not express the known receptors for MeV. Recent studies have revealed that certain changes in the ectodomain of the MeV fusion (F) protein play a key role in MeV spread in the brain. These changes destabilize the prefusion form of the F protein and render it hyperfusogenic, which in turn allows the virus to propagate in neurons. Based on crystal structures of the F protein, effective fusion inhibitors could be developed to treat these diseases.

元の言語英語
ページ(範囲)164-175
ページ数12
ジャーナルTrends in Microbiology
27
発行部数2
DOI
出版物ステータス出版済み - 2 1 2019

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Measles virus
Virus Diseases
Brain
Subacute Sclerosing Panencephalitis
Viral Fusion Proteins
Neurons
Neurodegenerative Diseases
Proteins
Viruses

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

これを引用

New Insights into Measles Virus Brain Infections. / Watanabe, Shumpei; Shirogane, Yuta; Sato, Yuma; Hashiguchi, Takao; Yanagi, Yusuke.

:: Trends in Microbiology, 巻 27, 番号 2, 01.02.2019, p. 164-175.

研究成果: ジャーナルへの寄稿評論記事

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