New insights into the function and regulation of mitochondrial fission

Hidenori Otera, Naotada Ishihara, Katsuyoshi Mihara

研究成果: Contribution to journalReview article査読

272 被引用数 (Scopus)

抄録

Mitochondrial morphology changes dynamically by coordinated fusion and fission and cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are required for the exchange of damaged mitochondrial genome DNA, proteins, and lipids with those of healthy mitochondria to maintain robust mitochondrial structure and function. These dynamics are crucial for cellular life and death, because they are essential for cellular development and homeostasis, as well as apoptosis. Disruption of these functions leads to cellular dysfunction, resulting in neurologic disorders and metabolic diseases. The cytoplasmic dynamin-related GTPase Drp1 plays a key role in mitochondrial fission, while Mfn1, Mfn2 and Opa1 are involved in fusion reaction. Here, we review current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission: the initial recruitment and assembly of Drp1 on the mitochondrial fission foci, regulation of Drp1 activity by post-translational modifications, and the role of mitochondrial fission in cell pathophysiology.

本文言語英語
ページ(範囲)1256-1268
ページ数13
ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
1833
5
DOI
出版ステータス出版済み - 5 2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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