New insights on glucosylated lipids: Metabolism and functions

Yohei Ishibashi, Ayako Kohyama-Koganeya, Yoshio Hirabayashi

研究成果: ジャーナルへの寄稿評論記事

43 引用 (Scopus)

抄録

Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the functional properties of lipids. For instance, ceramide acts as a strong tumor suppressor that causes apoptosis and cell cycle arrest, while GlcCer has an opposite effect, downregulating ceramide activities. All glucosylated lipids are enriched in lipid rafts or microdomains and play fundamental roles in a variety of cellular processes. In this review, we discuss the biological functions and metabolism of these three glucosylated lipids.

元の言語英語
ページ(範囲)1475-1485
ページ数11
ジャーナルBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
1831
発行部数9
DOI
出版物ステータス出版済み - 1 1 2013
外部発表Yes

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Lipid Metabolism
Ceramides
Lipids
Glucosylceramides
Phosphatidic Acids
Membrane Lipids
Cell Cycle Checkpoints
Down-Regulation
Cholesterol
Apoptosis
Glucose
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

これを引用

New insights on glucosylated lipids : Metabolism and functions. / Ishibashi, Yohei; Kohyama-Koganeya, Ayako; Hirabayashi, Yoshio.

:: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 巻 1831, 番号 9, 01.01.2013, p. 1475-1485.

研究成果: ジャーナルへの寄稿評論記事

Ishibashi, Yohei ; Kohyama-Koganeya, Ayako ; Hirabayashi, Yoshio. / New insights on glucosylated lipids : Metabolism and functions. :: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2013 ; 巻 1831, 番号 9. pp. 1475-1485.
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