New insights on glucosylated lipids: Metabolism and functions

Yohei Ishibashi, Ayako Kohyama-Koganeya, Yoshio Hirabayashi

研究成果: ジャーナルへの寄稿総説査読

79 被引用数 (Scopus)

抄録

Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the functional properties of lipids. For instance, ceramide acts as a strong tumor suppressor that causes apoptosis and cell cycle arrest, while GlcCer has an opposite effect, downregulating ceramide activities. All glucosylated lipids are enriched in lipid rafts or microdomains and play fundamental roles in a variety of cellular processes. In this review, we discuss the biological functions and metabolism of these three glucosylated lipids.

本文言語英語
ページ(範囲)1475-1485
ページ数11
ジャーナルBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
1831
9
DOI
出版ステータス出版済み - 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞生物学

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