New therapeutic strategy for cancer targeting the hedgehog signaling pathway

Masafumi Nakamura, Makoto Kubo, Shuntaro Nagai, Koji Yamaguchi, Masao Tanaka, Mitsuo Katano

研究成果: Contribution to journalArticle

4 引用 (Scopus)

抜粋

The hedgehog (Hh) signaling pathway was originally found as an organizer in embryonic development. The pathway is now implicated in the development of various tumors. Recently, it has been reported that the pathway activation is resulted from aberrant expression of the ligand, Sonic Hh (Shh), in pancreatic cancer and breast cancer. Here we developed a new strategy to control the activation of the Hh signaling pathway in cancer cells, which have ectopic and ligand dependent activation of the Hh signaling pathway. Our strategy may contribute to the development of a new cancer treatment.

元の言語英語
ページ(範囲)1914-1916
ページ数3
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
34
発行部数12
出版物ステータス出版済み - 11 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント New therapeutic strategy for cancer targeting the hedgehog signaling pathway' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用