New topics in vasopressin receptors and approach to novel drugs: Role of the vasopressin receptor in psychological and cognitive functions

Nobuaki Egashira, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

研究成果: Contribution to journalShort survey査読

37 被引用数 (Scopus)

抄録

Arginine vasopressin (AVP) is a neurohypophyseal peptide best known as an antidiuretic hormone. AVP receptors have been classified into three subtypes: V1a, V1b, and V2 receptors. V1a receptor (V1aR) and V1b receptor (V1bR) are widely distributed in the central nervous system, including the septum, cortex, hippocampus, and hypothalamus. Clinical studies have demonstrated an involvement of AVP in psychiatric disorders. In the present study, we examined the performance of V1aR or V1bR knockout (KO) mice compared to wild-type (WT) mice in behavioral tests. V1aR and V1bR KO mice exhibited deficits of social behavior and prepulse inhibition in comparison to WT mice. Moreover, V1aR KO mice exhibited reduced anxiety-like behavior and impairment of spatial learning. These results suggest that V1aR and V1bR play an important role in psychological and cognitive functions.

本文言語英語
ページ(範囲)44-49
ページ数6
ジャーナルJournal of Pharmacological Sciences
109
1
DOI
出版ステータス出版済み - 2009

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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