Next-generation optimized biotherapeutics - A review and preclinical study

研究成果: Contribution to journalReview article査読

17 被引用数 (Scopus)

抄録

Biotherapeutics have been clinically used since the 1990s. Recently, next-generation optimized biotherapeutics, which are expected to act on the same molecular target as their predecessors with further properties by antibody-drug conjugation, radiolabeling, PEGylation and glycoconjugation, are on the market. This article reviews recent next-generation optimized biotherapeutics. Moreover, since trials of protein engineering for biotherapeutics have been conducted, these preclinical approaches are also described. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody.

本文言語英語
ページ(範囲)2053-2057
ページ数5
ジャーナルBiochimica et Biophysica Acta - Proteins and Proteomics
1844
11
DOI
出版ステータス出版済み - 11 2014

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生物理学
  • 生化学
  • 分子生物学

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