NF-κB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis

T. Yamaza, K. F. Masuda, Y. Tsukiyama, K. Nishijima, R. Murakami, M. A. Kido, K. Koyano, T. Tanaka

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

NF-κB plays a pivotal role in pathogenesis in general arthritis. However, the participation of NF-κB in inflammation of the temporomandibular joint (TMJ) is poorly understood. We examined NF-κB expression in rat TMJs with synovitis induced by condyle hypermobility. By immunohistochemistry, NF-κB immunoreactivity was found mainly in the cytoplasm, not the nucleus, of the synovial lining cells of induced-synovitis and control TMJs. Southwestern histochemistry, a new method for detecting transcription factors, showed greater NF-κB expression in the nucleus of the synovial lining cells in the hypertrophic synovium than in control synovium. Increased numbers of the synovial lining cells with immunoreactivity for inducible nitric oxide synthase (iNOS), which is transcriptionally regulated by NF-κB, were also seen in the inflamed synovium. These findings indicate that excess mechanical stress increases NF-κB activation in the TMJ and suggest that active NF-κB is involved in the progression of TMJ inflammation.

本文言語英語
ページ(範囲)183-188
ページ数6
ジャーナルJournal of Dental Research
82
3
DOI
出版ステータス出版済み - 3 2003

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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