NF-κB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFα

Hideya Igarashi, Yoshihiro Baba, Yoshinori Nagai, Eijiro Jimi, Sankar Ghosh, Paul W. Kincade

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Levels of the nuclear factor-kappa B (NF-κB)/Rel family of proteins are carefully modulated in differentiating lymphocytes, where these transcription factors are thought to be important for survival and fate decisions. In contrast, gene-targeting experiments have not revealed clear roles for these transcription factors in lymphopoiesis within bone marrow. Inhibition of NF-κB by introduction of mutated IκBα, a 'superinhibitor' of NF-κB, into hematopoietic stem cells or early progenitors suppressed B as well as T lymphopoiesis following transplantation into immunodeficient mice. Furthermore, a NF-κB essential modifier-binding domain (NBD) peptide that blocks IKB kinase (IKK) activity selectively impaired the generation of adult B lineage cells. However, this suppression did not occur when a neutralizing antibody to tumor necrosis factor α (TNFα) was added to the cultures, or in circumstances where few non-lymphoid cells were present. We conclude that while NF-κB plays a survival-promoting role in lymphoid progenitors, this may only be significant in circumstances such as transplantation when levels of TNFα are high.

本文言語英語
ページ(範囲)653-659
ページ数7
ジャーナルInternational immunology
18
5
DOI
出版ステータス出版済み - 5 15 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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