Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats

Katsunori Iwasaki, Nobuaki Egashira, Yuki Takagaki, Yoshitaka Yoshimitsu, Izzettin Hatip-Al-Khatib, Kenichi Mishima, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and β-amyloid (Aβ). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).

本文言語英語
ページ(範囲)698-701
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
30
4
DOI
出版ステータス出版済み - 4 1 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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