Nitrene Transfer Reactions for Asymmetric C–H Amination: Recent Development

Hiroki Hayashi, Tatsuya Uchida

研究成果: Contribution to journalReview article査読

38 被引用数 (Scopus)


C–H bonds are ubiquitous and abundant in organic molecules. If C–H bonds could be directly converted to desired functional groups in a chemo-, site-, and stereoselective manner, C–H functionalization would be a strong and useful tool for organic synthesis. Recent developments in catalytic and enzymatic chemistry have achieved highly sustainable and selective nitrene C–H insertion. Initially, C–H amination was inspired by model studies on enzymatic oxidation and used iminoiodinanes, nitrogen analogs of iodosobenzene, as nitrene precursors. Transition-metal/iminoiodinane systems are well studied and established. These systems can directly introduce sulfonamide groups with excellent stereoselectivity, albeit with co-production of iodobenzene as waste material. Fortunately, the atom economics of this methodology were improved by introducing highly sustainable nitrene sources such as azide compounds and 1,2,4-dioxazol-5-one derivatives. In this review, we present the details of these developments with respect to their catalysts and nitrene sources.

ジャーナルEuropean Journal of Organic Chemistry
出版ステータス出版済み - 2 28 2020

All Science Journal Classification (ASJC) codes

  • 物理化学および理論化学
  • 有機化学


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