No requirement for p56lck in the antigen-stimulated clonal deletion of thymocytes

Kei Ichi Nakayama, Dennis Y. Loh

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)

抄録

Activation of protein-tyrosine kinases (PTKs) is required for signal transduction during T cell activation, although the pathway used during thymic selection is unknown. An in vitro system was established in which T cell receptor transgenic thymocytes underwent clonal deletion in response to peptide antigen. The effects of two PTK-specific inhibitors, herbimycin A and genistein, on the clonal deletion of immature thymocytes and the activation of mature thymocytes were examined. Clonal deletion occurred while T cell activation was inhibited and when no p56lck activity was evident. Thus, p56 lck is not required for the antigen-stimulated step of clonal deletion of immature thymocytes, and negative selection proceeds via a distinct pathway.

本文言語英語
ページ(範囲)94-96
ページ数3
ジャーナルScience
257
5066
DOI
出版ステータス出版済み - 1992
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 一般

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