Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Masamichi Yamamoto, Yukio Saijoh, Altana Perea-Gomez, William Shawiot, Richard R. Behringer, Siew Lan Ang, Hiroshi Hamada, Chikara Meno

研究成果: Contribution to journalArticle査読

212 被引用数 (Scopus)

抄録

Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.

本文言語英語
ページ(範囲)387-392
ページ数6
ジャーナルNature
428
6981
DOI
出版ステータス出版済み - 3 25 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

フィンガープリント

「Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル