Non-C2-symmetric, chirally economical, and readily tunable linked-binols: Design and application in a direct catalytic asymmetric mannich-type reaction

Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga, Masakatsu Shibasaki

研究成果: ジャーナルへの寄稿記事

67 引用 (Scopus)

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(Chemical Equation Presented) An achiral unit is shown to be better than a chiral unit in promoting an asymmetric reaction. Non-C2-symmetric linked-binols 1 with one chiral 1,1′-bi-2-naphthol unit and one flexible achiral unit are employed as ligands in direct catalytic asymmetric Mannich-type reactions (see scheme; TON = turnover number). With as little as 0.01 mol% of ligand 1 a and 0.04 mol% of Et2Zn, the reaction proceeded smoothly to give the product in 98% ee.

元の言語英語
ページ(範囲)3470-3474
ページ数5
ジャーナルAngewandte Chemie - International Edition
44
発行部数22
DOI
出版物ステータス出版済み - 5 30 2005
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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