Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly

Guoqing Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

研究成果: 著書/レポートタイプへの貢献

抄録

A gold nanoparticle densely modified with DNA (DNA 'AuNP), which integrates the ability of molecular recognition with plasmonic properties, is a well-established platform in nanobiotechnology. Both in analytical science and materials science, DNA 'AuNP assemblies crosslinked by Watson-Crick base pairing have gained great popularity. Yet the finding of non-crosslinking aggregation of DNA 'AuNPs has brought us to another fascinating side of this material. Upon hybridization with the complementary DNA, the DNA 'AuNPs undergo a dramatic decrease in colloidal stability accompanied with a distinct color change due to blunt-end stacking interactions. When hybridized to the terminal-mismatched DNA, the DNA 'AuNPs stay dispersed even at high ionic strength by virtue of fraying motion of the outmost unpaired nucleobases. This distinct colloidal phenomenon provides a colorimetric approach to discriminate single-nucleotide polymorphisms. Furthermore, by region-specific arrangement of single-base pairing/unpairing at the outmost surface of the DNA layer, gold nanorods can spontaneously evolve to assemble in an orientation-controlled fashion, promising applications in fabrication of various nanodevices.

元の言語英語
ホスト出版物のタイトルTargeted Nanosystems for Therapeutic Applications
ホスト出版物のサブタイトルNew Concepts, Dynamic Properties, Efficiency, and Toxicity
編集者Kazuo Sakurai, Marc A. Ilies
出版者American Chemical Society
ページ119-138
ページ数20
ISBN(電子版)9780841233836
DOI
出版物ステータス出版済み - 1 1 2019

出版物シリーズ

名前ACS Symposium Series
1309
ISSN(印刷物)0097-6156
ISSN(電子版)1947-5918

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Gold
DNA
Agglomeration
Genes
Nanoparticles
Nanobiotechnology
Molecular recognition
Materials science
Ionic strength
Polymorphism
Nanorods
Nucleotides
Complementary DNA
Color
Fabrication

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

これを引用

Wang, G., Akiyama, Y., Kanayama, N., Takarada, T., & Maeda, M. (2019). Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly. : K. Sakurai, & M. A. Ilies (版), Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity (pp. 119-138). (ACS Symposium Series; 巻数 1309). American Chemical Society. https://doi.org/10.1021/bk-2019-1309.ch006

Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly. / Wang, Guoqing; Akiyama, Yoshitsugu; Kanayama, Naoki; Takarada, Tohru; Maeda, Mizuo.

Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. 版 / Kazuo Sakurai; Marc A. Ilies. American Chemical Society, 2019. p. 119-138 (ACS Symposium Series; 巻 1309).

研究成果: 著書/レポートタイプへの貢献

Wang, G, Akiyama, Y, Kanayama, N, Takarada, T & Maeda, M 2019, Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly. : K Sakurai & MA Ilies (版), Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. ACS Symposium Series, 巻. 1309, American Chemical Society, pp. 119-138. https://doi.org/10.1021/bk-2019-1309.ch006
Wang G, Akiyama Y, Kanayama N, Takarada T, Maeda M. Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly. : Sakurai K, Ilies MA, 編集者, Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. American Chemical Society. 2019. p. 119-138. (ACS Symposium Series). https://doi.org/10.1021/bk-2019-1309.ch006
Wang, Guoqing ; Akiyama, Yoshitsugu ; Kanayama, Naoki ; Takarada, Tohru ; Maeda, Mizuo. / Non-crosslinking aggregation of DNA-functionalized gold nanoparticles for gene diagnosis and directed assembly. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. 編集者 / Kazuo Sakurai ; Marc A. Ilies. American Chemical Society, 2019. pp. 119-138 (ACS Symposium Series).
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