Non-decay type fast-setting calcium phosphate cement: Setting behaviour in calf serum and its tissue response

Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Miwako Yuasa, Masayuki Kon, Masaru Nagayama, Kenzo Asaoka

研究成果: ジャーナルへの寄稿記事

76 引用 (Scopus)

抄録

Non-decay type fast-setting calcium phosphate cement (nd-FSCPC) was evaluated in terms of its setting behaviour in calf serum and its tissue response to investigate the feasibility of its clinical use in surgical applications. Non-decay type cements were prepared by adding various amounts of sodium alginate to the liquid phase of base cements, fast-setting calcium phosphate cement (FSCPC) and conventional calcium phosphate cement (c-CPC). Cement pastes were immersed in serum at 37°C immediately after mixing, and decay behaviour, setting time and mechanical strength were measured to evaluate the possibility of their use in surgical applications. Also, nd-FSCPC was implanted into rat subcutaneous tissue for the initial evaluation of biocompatibility of this potential bioactive cement. nd-FSCPC set in approximately 6-7 min in serum, even when the cement paste was immersed in the serum immediately after mixing, whereas c-CPC and FSCPC decayed completely upon immersion. nd-FSCPC transforms to hydroxyapatite (HA) within 24 h and shows a diametral tensile strength of approximately 4-5 MPa. As a result of transformation to HA, nd-FSCPC showed excellent tissue response when implanted subcutaneously in rats. We conclude that nd-FSCPC has good potential value for use in orthopaedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement is exposed to blood.

元の言語英語
ページ(範囲)1429-1435
ページ数7
ジャーナルBiomaterials
17
発行部数14
DOI
出版物ステータス出版済み - 1 1 1996
外部発表Yes

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Calcium phosphate
Cements
Tissue
Serum
Oral Surgery
Durapatite
Ointments
Reconstructive Surgical Procedures
calcium phosphate
Hydroxyapatite
Surgery
Tensile Strength
Subcutaneous Tissue
Rats
Immersion
Plastic Surgery
Orthopedics
Sodium alginate
Biocompatibility
Strength of materials

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

これを引用

Non-decay type fast-setting calcium phosphate cement : Setting behaviour in calf serum and its tissue response. / Miyamoto, Youji; Ishikawa, Kunio; Takechi, Masaaki; Yuasa, Miwako; Kon, Masayuki; Nagayama, Masaru; Asaoka, Kenzo.

:: Biomaterials, 巻 17, 番号 14, 01.01.1996, p. 1429-1435.

研究成果: ジャーナルへの寄稿記事

Miyamoto, Youji ; Ishikawa, Kunio ; Takechi, Masaaki ; Yuasa, Miwako ; Kon, Masayuki ; Nagayama, Masaru ; Asaoka, Kenzo. / Non-decay type fast-setting calcium phosphate cement : Setting behaviour in calf serum and its tissue response. :: Biomaterials. 1996 ; 巻 17, 番号 14. pp. 1429-1435.
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