Noninvasive assessment of liver fibrosis by dual-layer spectral detector CT

Koichiro Morita, Akihiro Nishie, Yasuhiro Ushijima, Yukihisa Takayama, Nobuhiro Fujita, Yuichiro Kubo, Keisuke Ishimatsu, Tomoharu Yoshizumi, Junki Maehara, Kousei Ishigami

研究成果: Contribution to journalArticle査読

抄録

Purpose: To elucidate the diagnostic ability of liver fibrosis using (1) liver parenchymal iodine density on equilibrium computed tomographic imaging and (2) extracellular volume (ECV) measured by dual-layer spectral detector CT. Methods: From April 2018 to June 2019, 68 patients [mean age, 62 years; 39 males, 29 females] underwent dynamic contrast-enhanced CT by a dual-layer spectral detector CT system before liver transplantation or liver resection. The iodine densities of liver parenchyma (I liver) and aorta (I aorta) were independently measured by two radiologists at the equilibrium phase. The iodine-density ratio (I-ratio) (I liver/ I aorta) and the CT-ECV were calculated. Spearman's rank correlation coefficient was used to analyze the relationship between the I-ratio or the CT-ECV and the fibrosis stage. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of the I-ratio and the CT-ECV for discriminating fibrosis stages. Results: For both readers, the I-ratio and the CT-ECV increased significantly as the fibrosis stage advanced (I-ratio: rho = 0.380 and 0.443, p < 0.01; CT-ECV: rho = 0.423 and 0.469, p < 0.01). The CT-ECV showed better diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating F4 stage were 0.884 and 0.925. The two readers' cutoff values of the CT-ECV for diagnosing fibrosis as F4 were 26.2 % and 29.3 %, with 95.0 % and 90.0 % sensitivity and 72.9 % and 85.4 % specificity, respectively. Conclusion: The liver parenchymal iodine density on the equilibrium phase and the CT-ECV can be useful for predicting a high stage of liver fibrosis.

本文言語英語
論文番号109575
ジャーナルEuropean Journal of Radiology
136
DOI
出版ステータス出版済み - 3 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

フィンガープリント 「Noninvasive assessment of liver fibrosis by dual-layer spectral detector CT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル