Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Eriko Nagasawa, Yasunobu Abe, Takamitsu Matsushima, Ilseung Choi, Yoshimichi Tachikawa, Rie Ohtsuka, Hideki Ishikura, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

研究成果: Contribution to journalArticle

抜粋

We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

元の言語英語
ページ(範囲)167-169
ページ数3
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
45
発行部数2
出版物ステータス出版済み - 2 2004

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Nagasawa, E., Abe, Y., Matsushima, T., Choi, I., Tachikawa, Y., Ohtsuka, R., Ishikura, H., Nishimura, J., Inaba, S., Nawata, H., & Muta, K. (2004). Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia. [Rinshō ketsueki] The Japanese journal of clinical hematology, 45(2), 167-169.