NOTCH4 is a potential therapeutic target for triple-negative breast cancer

Iori Nagamatsu, Hideya Onishi, Shojiro Matsushita, Makoto Kubo, Masaya Kai, Akira Imaizumi, kenji nakano, Masami Hattori, Yoshinao Oda, Masao Tanaka, Mitsuo Katano

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)

抄録

Background/Aim: The prognosis for triple-negative breast cancer (TNBC) is poor. In the present study, we evaluated whether NOTCH4 receptor is a potential new therapeutic target for TNBC. Materials and Methods: In vitro proliferation and invasiveness were evaluated in TNBC cells with or without small-interfering RNA (siRNA) for NOTCH4, and with or without NOTCH4 plasmid transfection. In vivo, MDA-MB-231 cells with or without NOTCH4 siRNA were subcutaneously implanted into the flank regions of mice. The frequency of nuclear translocation of NOTCH4 was assessed by immunohistochemistry in 21 TNBC samples and 46 non-TNBC samples. Results: NOTCH4 inhibition in TNBC cells reduced proliferation and invasiveness, and NOTCH4 overexpression in TNBC cells increased proliferation and invasiveness. NOTCH4 inhibition reduced tumour volume and tumourigenicity of mouse xenografts. TNBC cells had a higher frequency of nuclear translocation of NOTCH4 than other cells. Conclusion: NOTCH4 is a new potential therapeutic target for triple-negative breast cancer.

本文言語英語
ページ(範囲)69-80
ページ数12
ジャーナルAnticancer research
34
1
出版ステータス出版済み - 1月 1 2014

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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