NRF2 Activation inhibits both tgf- β 1- and il-13-mediated periostin expression in fibroblasts: Benefit of cinnamaldehyde for antifibrotic treatment

Yasutaka Mitamura, Mika Murai, Chikage Mitoma, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

元の言語英語
記事番号2475047
ジャーナルOxidative medicine and cellular longevity
2018
DOI
出版物ステータス出版済み - 1 1 2018

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Fibroblasts
Chemical activation
Interleukin-13
Skin
Oxidative stress
Extracellular Matrix
Reactive Oxygen Species
Oxidative Stress
Up-Regulation
Down-Regulation
Antioxidants
cinnamic aldehyde
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology

これを引用

NRF2 Activation inhibits both tgf- β 1- and il-13-mediated periostin expression in fibroblasts : Benefit of cinnamaldehyde for antifibrotic treatment. / Mitamura, Yasutaka; Murai, Mika; Mitoma, Chikage; Furue, Masutaka.

:: Oxidative medicine and cellular longevity, 巻 2018, 2475047, 01.01.2018.

研究成果: ジャーナルへの寄稿記事

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title = "NRF2 Activation inhibits both tgf- β 1- and il-13-mediated periostin expression in fibroblasts: Benefit of cinnamaldehyde for antifibrotic treatment",
abstract = "Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.",
author = "Yasutaka Mitamura and Mika Murai and Chikage Mitoma and Masutaka Furue",
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T1 - NRF2 Activation inhibits both tgf- β 1- and il-13-mediated periostin expression in fibroblasts

T2 - Benefit of cinnamaldehyde for antifibrotic treatment

AU - Mitamura, Yasutaka

AU - Murai, Mika

AU - Mitoma, Chikage

AU - Furue, Masutaka

PY - 2018/1/1

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N2 - Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

AB - Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

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