TY - JOUR
T1 - Nrf2 contributes to the weight gain of mice during space travel
AU - Suzuki, Takafumi
AU - Uruno, Akira
AU - Yumoto, Akane
AU - Taguchi, Keiko
AU - Suzuki, Mikiko
AU - Harada, Nobuhiko
AU - Ryoke, Rie
AU - Naganuma, Eriko
AU - Osanai, Nanae
AU - Goto, Aya
AU - Suda, Hiromi
AU - Browne, Ryan
AU - Otsuki, Akihito
AU - Katsuoka, Fumiki
AU - Zorzi, Michael
AU - Yamazaki, Takahiro
AU - Saigusa, Daisuke
AU - Koshiba, Seizo
AU - Nakamura, Takashi
AU - Fukumoto, Satoshi
AU - Ikehata, Hironobu
AU - Nishikawa, Keizo
AU - Suzuki, Norio
AU - Hirano, Ikuo
AU - Shimizu, Ritsuko
AU - Oishi, Tetsuya
AU - Motohashi, Hozumi
AU - Tsubouchi, Hirona
AU - Okada, Risa
AU - Kudo, Takashi
AU - Shimomura, Michihiko
AU - Kensler, Thomas W.
AU - Mizuno, Hiroyasu
AU - Shirakawa, Masaki
AU - Takahashi, Satoru
AU - Shiba, Dai
AU - Yamamoto, Masayuki
N1 - Funding Information:
We would like to thank Norishige Kanai (astronaut) for the onboard operation, and Toshiaki Kokubo and Noriko Kajiwara (JAXA visiting veterinarians) for monitoring mouse health. We also thank Naoko Ota-Murakami, Fumika Yamaguchi, Masumi Umehara, and the members of the mouse health check team, for performing daily onboard health checks, Ramona Bober, Autumn L. Cdebaca, Rebecca A. Smith for animal care and ground experiment supports, Hirochika Murase, Hiroaki Kodama, Yusuke Hagiwara, and members of hardware development team for MHU hardware preparation and operations, Kohei Hirakawa, Teruhiro Senkoji, Haruna Tanii, Motoki Tada, Yuki Watanabe, Kayoko Lino, Hiromi Sano, Yui Nakata, Hiromi Suzuki-Hashi-zume, Eiji Ohta, Osamu Funatsu, Hideaki Hotta, Hatsumi Ishida, Mariko Shimizu, and members of JEM operational team for the research coordination, Takahashi Ueda and Tomohiro Tamari for animal preparations, Hong Xin and Grishma Acharya for landing site operational supports, and Sayaka Umemura, Laura Lewis, Charles E. Hopper, Jen-nifer J. Scott Williams, Robert Kuczajda for international coordination. This work was selected as a space rodent research study for JAXA’s feasibility experiments using ISS/ Kibo announced in 2015, and also supported in part by MEXT/JSPS KAKENHI (19H05649 to M.Y. and 17KK0183, 18H04963, 19K07340, to T. Suzuki), Takeda Science Foundation (M.Y., and T. Suzuki.) and the Smart Aging Research Center, Tohoku University (M.Y.). This work was also supported in part by the grants JP19km0105001, JP19km0105002 and SHARE.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Space flight produces an extreme environment with unique stressors, but little is known about how our body responds to these stresses. While there are many intractable limitations for in-flight space research, some can be overcome by utilizing gene knockout-disease model mice. Here, we report how deletion of Nrf2, a master regulator of stress defense pathways, affects the health of mice transported for a stay in the International Space Station (ISS). After 31 days in the ISS, all flight mice returned safely to Earth. Transcriptome and metabolome analyses revealed that the stresses of space travel evoked ageing-like changes of plasma metabolites and activated the Nrf2 signaling pathway. Especially, Nrf2 was found to be important for maintaining homeostasis of white adipose tissues. This study opens approaches for future space research utilizing murine gene knockout-disease models, and provides insights into mitigating space-induced stresses that limit the further exploration of space by humans.
AB - Space flight produces an extreme environment with unique stressors, but little is known about how our body responds to these stresses. While there are many intractable limitations for in-flight space research, some can be overcome by utilizing gene knockout-disease model mice. Here, we report how deletion of Nrf2, a master regulator of stress defense pathways, affects the health of mice transported for a stay in the International Space Station (ISS). After 31 days in the ISS, all flight mice returned safely to Earth. Transcriptome and metabolome analyses revealed that the stresses of space travel evoked ageing-like changes of plasma metabolites and activated the Nrf2 signaling pathway. Especially, Nrf2 was found to be important for maintaining homeostasis of white adipose tissues. This study opens approaches for future space research utilizing murine gene knockout-disease models, and provides insights into mitigating space-induced stresses that limit the further exploration of space by humans.
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U2 - 10.1038/s42003-020-01227-2
DO - 10.1038/s42003-020-01227-2
M3 - Article
C2 - 32901092
AN - SCOPUS:85090386690
SN - 2399-3642
VL - 3
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 496
ER -