Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

M. Elsbaey, Bai Jie, Chiaki Tanaka, Hikaru Kato, Sachiko Tsukamoto, Kazuteru Usui, Go Hirai, Tomofumi Miyamoto

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.

本文言語英語
論文番号150948
ジャーナルTetrahedron Letters
60
33
DOI
出版ステータス出版済み - 8 15 2019

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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