Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

M. Elsbaey, Bai Jie, Chiaki Tanaka, Hikaru Kato, Sachiko Tsukamoto, Kazuteru Usui, Go Hirai, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿記事

抄録

Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.

元の言語英語
記事番号150948
ジャーナルTetrahedron Letters
60
発行部数33
DOI
出版物ステータス出版済み - 8 15 2019

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Cocos
Scavenging
Neuroprotective Agents
Cell death
Skeleton
Assays
Cell Death
Nuclear magnetic resonance
ethyl acetate

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

これを引用

Nuciferols A and B : Novel sesquineolignans from Cocos nucifera. / Elsbaey, M.; Jie, Bai; Tanaka, Chiaki; Kato, Hikaru; Tsukamoto, Sachiko; Usui, Kazuteru; Hirai, Go; Miyamoto, Tomofumi.

:: Tetrahedron Letters, 巻 60, 番号 33, 150948, 15.08.2019.

研究成果: ジャーナルへの寄稿記事

Elsbaey, M. ; Jie, Bai ; Tanaka, Chiaki ; Kato, Hikaru ; Tsukamoto, Sachiko ; Usui, Kazuteru ; Hirai, Go ; Miyamoto, Tomofumi. / Nuciferols A and B : Novel sesquineolignans from Cocos nucifera. :: Tetrahedron Letters. 2019 ; 巻 60, 番号 33.
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