Nuclear atypia grading score is a useful prognostic factor in papillary gastric adenocarcinoma

Yuichiro Nakashima, Takashi Yao, Minako Hirahashi, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara, Masazumi Tsuneyoshi

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)


Aims: To investigate nuclear atypical in papillary gastric adenocarcinoma (PGA). Method and results: Hundred cases of PGA were classified into two groups according to nuclear pleomorphism and nuclear polarity; these groups were designated as high nuclear grade and low nuclear grade. Correlations between nuclear grade and clinicopathological features were evaluated for prognostic value. In order to evaluate which types of biological factors influence nuclear atypia, the expression of gastric-type mucin phenotype, p53, HER2 and Ki-67 detected by immunohistochemistry and DNA ploidy detected by laser scanning cytometry. The high nuclear grade group correlated with deeper wall invasion, the presence of lymphatic and venous invasion and the positivity of lymph node metastasis. High nuclear grade was an independent prognostic factor for disease-free survival. Moreover, significant correlations were observed between high nuclear grade and positivity of gastric-type mucin phenotype, p53 and HER2 and DNA aneuploidy. Conclusion: Nuclear grade could be a new and useful morphological predictor for high malignant potential in PGA.

出版ステータス出版済み - 11 2011

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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