Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Akio Yamasaki, Chizu Kameda, Rui Xu, Haruo Tanaka, Takehiko Tasaka, Nobuhito Chikazawa, Hiroyuki Suzuki, Takashi Morisaki, Makoto Kubo, Hideya Onishi, Masao Tanaka, M. Katano

研究成果: ジャーナルへの寄稿学術誌査読

40 被引用数 (Scopus)

抄録

Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammationstimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.

本文言語英語
ページ(範囲)675-686
ページ数12
ジャーナルCancer Immunology, Immunotherapy
59
5
DOI
出版ステータス出版済み - 5月 2010

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 腫瘍学
  • 癌研究

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