NY-ESO-1 antibody as a novel tumour marker of gastric cancer

S. Fujiwara, H. Wada, J. Kawada, R. Kawabata, T. Takahashi, J. Fujita, T. Hirao, K. Shibata, Y. Makari, S. Iijima, H. Nishikawa, A. A. Jungbluth, Y. Nakamura, Y. Kurokawa, M. Yamasaki, H. Miyata, K. Nakajima, S. Takiguchi, E. Nakayama, M. MoriY. Doki

研究成果: Contribution to journalArticle査読

29 被引用数 (Scopus)

抄録

Background: NY-ESO-1 antibodies are specifically observed in patients with NY-ESO-1-expressing tumours. We analysed whether the NY-ESO-1 humoral immune response is a useful tumour marker of gastric cancer. Methods: Sera from 363 gastric cancer patients were screened by enzyme-linked immunosorbent assay (ELISA) to detect NY-ESO-1 antibodies. Serial serum samples were obtained from 25 NY-ESO-1 antibody-positive patients, including 16 patients with curative resection and 9 patients who received chemotherapy alone.Results:NY-ESO-1 antibodies were detected in 3.4% of stage I, 4.4% of stage II, 25.3% of stage III, and 20.0% of stage IV patients. The frequency of antibody positivity increased with disease progression. When the NY-ESO-1 antibody was used in combination with carcinoembryonic antigen and CA19-9 to detect gastric cancer, information gains of 11.2% in stages III and IV, and 5.8% in all patients were observed. The NY-ESO-1 immune response levels of the patients without recurrence fell below the cutoff level after surgery. Two of the patients with recurrence displayed incomplete decreases. The nine patients who received chemotherapy alone continued to display NY-ESO-1 immune responses. Conclusion: When combined with conventional tumour markers, the NY-ESO-1 humoral immune response could be a useful tumour marker for detecting advanced gastric cancer and inferring the post-treatment tumour load in seropositive patients.

本文言語英語
ページ(範囲)1119-1125
ページ数7
ジャーナルBritish journal of cancer
108
5
DOI
出版ステータス出版済み - 3 19 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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