O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) uptake in mouse thymoma cells, and its biodistribution in mice and human volunteers

K. Abe, K. Hayashi, M. Sasaki, H. Koga, K. Kaneko, H. Sawamoto, K. Himuro, Hiroshi Honda

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Purpose: To evaluate O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) uptake in mouse malignant thymoma (EL4), and its biodistribution in mice and humans.

Material and Methods: First, 18F-FET uptake in EL4 cells was examined in an in vitro study. Second, the kinetics of 18F-FET uptake and its biodistribution were examined in mice after subcutaneous injection of EL4 cells and complete Freund's adjuvant. Finally, the kinetics of 18F-FET uptake and its biodistribution in healthy human volunteers were examined.

Results: In an in vitro study, 18F-FET was extensively incorporated in EL4 cells. In an animal study, 18F-FET accumulation in normal organs peaked within 30 min postinjection. The mean ratios of 18F-FET uptake in tumors and in inflammatory lesions to that in muscle tissue at 60 min postadministration were 2.18 (range 2.00-2.29) and 1.04 (range 0.95-1.14), respectively. In a human study, static images were taken 60 min after 18F-FET administration. Mean standardized uptake values (SUVs) of the liver (1.52, range 1.38-1.71) and kidneys (1.90, range 1.74-2.24) were nearly equal or slightly higher than that of muscle tissue (1.19, range 0.99-1.33).

Conclusion: This study demonstrates that 18F-FET accumulation in thymoma is significantly higher than in normal organs. 18F-FET could be a useful tracer for tumor imaging.

本文言語英語
ページ(範囲)1042-1048
ページ数7
ジャーナルActa Radiologica
47
10
DOI
出版ステータス出版済み - 12月 1 2006

!!!All Science Journal Classification (ASJC) codes

  • 放射線技術および超音波技術
  • 放射線学、核医学およびイメージング

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