Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells

Joseph T. Opferman, Hiromi Iwasaki, Christy C. Ong, Heikyung Suh, Shin Ichi Mizuno, Koichi Akashi, Stanley J. Korsmeyer

研究成果: Contribution to journalArticle査読

452 被引用数 (Scopus)

抄録

Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not precisely defined. We tested myeloid leukemia-1 (MCL-1) as an attractive candidate that is highly expressed in HSCs and regulated by growth factor signals. Inducible deletion of Mcl-1 in mice resulted in ablation of bone marrow. This resulted in the loss of early bone marrow progenitor populations, including HSCs. Moreover, growth factors including stem cell factor increased transcription of the Mcl-1 gene and required MCL-1 to augment survival of purified bone marrow progenitors. Deletion of Mcl-1 in other tissues, including liver, did not impair survival. Thus, MCL-1 is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors.

本文言語英語
ページ(範囲)1101-1104
ページ数4
ジャーナルScience
307
5712
DOI
出版ステータス出版済み - 2 18 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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