TY - JOUR
T1 - Occipital lobe gray matter volume in male patients with chronic schizophrenia
T2 - A quantitative MRI study
AU - Onitsuka, Toshiaki
AU - McCarley, Robert W.
AU - Kuroki, Noriomi
AU - Dickey, Chandlee C.
AU - Kubicki, Marek
AU - Demeo, Susan S.
AU - Frumin, Melissa
AU - Kikinis, Ron
AU - Jolesz, Ferenc A.
AU - Shenton, Martha E.
N1 - Funding Information:
This study was supported, in part, by the Department of Veterans Affairs Merit Awards and Research Enhancement Award Program (Drs. McCarley and Shenton), grants from the National Institute of Health (R01 MH 40799 to Dr. McCarley and K02 MH 01110 and R01 MH 50747 to Dr. Shenton), the MIND Institute (Albuquerque, NM, Dr. McCarley) a VA Career Award (Dr. Frumin), in part from the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant U54 EB005149 (Dr. Kikinis), and the Welfide Medicinal Research Foundation, Osaka, Japan (Dr. Onitsuka). The authors gratefully acknowledge the administrative support of Marie M. Fairbanks and Nancy Maxwell, and the research assistant support of Lisa C. Lucia, B.S., Meredith C. Klump, B.A., and Sarah M. Rabbitt, B.A.
PY - 2007/5
Y1 - 2007/5
N2 - Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia.
AB - Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia.
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U2 - 10.1016/j.schres.2007.01.027
DO - 10.1016/j.schres.2007.01.027
M3 - Article
C2 - 17350226
AN - SCOPUS:34147219002
SN - 0920-9964
VL - 92
SP - 197
EP - 206
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
