Odorant receptor-derived cAMP signals direct axonal targeting

Takeshi Imai, Misao Suzuki, Hitoshi Sakano

研究成果: ジャーナルへの寄稿記事

204 引用 (Scopus)

抄録

In mammals, odorant receptors (ORs) direct the axons of olfactory sensory neurons (OSNs) toward targets in the olfactory bulb. We show that cyclic adenosine monophosphate (cAMP) signals that regulate the expression of axon guidance molecules are essential for the OR-instructed axonal projection. Genetic manipulations of ORs, stimulatory G protein, cAMP-dependent protein kinase, and cAMP response element-binding protein shifted the axonal projection sites along the anterior-posterior axis in the olfactory bulb. Thus, it is the OR-derived cAMP signals, rather than direct action of OR molecules, that determine the target destinations of OSNs.

元の言語英語
ページ(範囲)657-661
ページ数5
ジャーナルScience
314
発行部数5799
DOI
出版物ステータス出版済み - 10 27 2006

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Odorant Receptors
Cyclic AMP
Olfactory Receptor Neurons
Olfactory Bulb
Response Elements
Cyclic AMP-Dependent Protein Kinases
GTP-Binding Proteins
Axons
Mammals
Carrier Proteins

All Science Journal Classification (ASJC) codes

  • General

これを引用

Odorant receptor-derived cAMP signals direct axonal targeting. / Imai, Takeshi; Suzuki, Misao; Sakano, Hitoshi.

:: Science, 巻 314, 番号 5799, 27.10.2006, p. 657-661.

研究成果: ジャーナルへの寄稿記事

Imai, Takeshi ; Suzuki, Misao ; Sakano, Hitoshi. / Odorant receptor-derived cAMP signals direct axonal targeting. :: Science. 2006 ; 巻 314, 番号 5799. pp. 657-661.
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