抄録
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/ sorting molecules, and thereby direct glomerular positioning and axon sorting.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Chemosensory Systems in Mammals, Fishes, and Insects |
| 編集者 | Wolfgang Meyerhof, Sigrun Korsching |
| ページ | 57-75 |
| ページ数 | 19 |
| DOI | |
| 出版物ステータス | 出版済み - 5 11 2009 |
出版物シリーズ
| 名前 | Results and Problems in Cell Differentiation |
|---|---|
| 巻 | 47 |
| ISSN（印刷物） | 0080-1844 |
| ISSN（電子版） | 1861-0412 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology
これを引用
Odorant receptor gene choice and axonal projection in the mouse olfactory system. / Imai, T.; Sakano, H.
Chemosensory Systems in Mammals, Fishes, and Insects. 版 / Wolfgang Meyerhof; Sigrun Korsching. 2009. p. 57-75 (Results and Problems in Cell Differentiation; 巻 47).研究成果: 著書/レポートタイプへの貢献 › 章
}
TY - CHAP
T1 - Odorant receptor gene choice and axonal projection in the mouse olfactory system
AU - Imai, T.
AU - Sakano, H.
PY - 2009/5/11
Y1 - 2009/5/11
N2 - In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/ sorting molecules, and thereby direct glomerular positioning and axon sorting.
AB - In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/ sorting molecules, and thereby direct glomerular positioning and axon sorting.
UR - http://www.scopus.com/inward/record.url?scp=65449169587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65449169587&partnerID=8YFLogxK
U2 - 10.1007/400_2008_3
DO - 10.1007/400_2008_3
M3 - Chapter
C2 - 19083127
AN - SCOPUS:65449169587
SN - 9783540699187
T3 - Results and Problems in Cell Differentiation
SP - 57
EP - 75
BT - Chemosensory Systems in Mammals, Fishes, and Insects
A2 - Meyerhof, Wolfgang
A2 - Korsching, Sigrun
ER -