Odorant receptor gene choice and axonal projection in the mouse olfactory system

T. Imai, H. Sakano

研究成果: Chapter in Book/Report/Conference proceedingChapter

17 被引用数 (Scopus)

抄録

In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/ sorting molecules, and thereby direct glomerular positioning and axon sorting.

本文言語英語
ホスト出版物のタイトルChemosensory Systems in Mammals, Fishes, and Insects
編集者Wolfgang Meyerhof, Sigrun Korsching
ページ57-75
ページ数19
DOI
出版ステータス出版済み - 5 11 2009
外部発表はい

出版物シリーズ

名前Results and Problems in Cell Differentiation
47
ISSN(印刷版)0080-1844
ISSN(電子版)1861-0412

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

フィンガープリント 「Odorant receptor gene choice and axonal projection in the mouse olfactory system」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル