Odorant receptor-mediated signaling in the mouse

Takeshi Imai, Hitoshi Sakano

研究成果: ジャーナルへの寄稿評論記事

41 引用 (Scopus)

抄録

In the mouse olfactory system, there are ∼1000 types of odorant receptors (ORs), which perform multiple functions in olfactory sensory neurons (OSNs). In addition to detecting odors, the functional OR protein ensures the singular gene choice of the OR by negative-feedback regulation. ORs also direct the axonal projection of OSNs both globally and locally by modulating the transcriptional levels of axon-guidance and axon-sorting molecules. In these latter processes, the second messenger, cAMP, plays differential roles in the fasciculation and targeting of axons. In this review, we will discuss how ORs differentially regulate intracellular signals for distinct functions.

元の言語英語
ページ(範囲)251-260
ページ数10
ジャーナルCurrent Opinion in Neurobiology
18
発行部数3
DOI
出版物ステータス出版済み - 6 1 2008
外部発表Yes

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Odorant Receptors
Olfactory Receptor Neurons
Second Messenger Systems
Axons
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Odorant receptor-mediated signaling in the mouse. / Imai, Takeshi; Sakano, Hitoshi.

:: Current Opinion in Neurobiology, 巻 18, 番号 3, 01.06.2008, p. 251-260.

研究成果: ジャーナルへの寄稿評論記事

Imai, Takeshi ; Sakano, Hitoshi. / Odorant receptor-mediated signaling in the mouse. :: Current Opinion in Neurobiology. 2008 ; 巻 18, 番号 3. pp. 251-260.
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