Odorant receptor-mediated signaling in the mouse

Takeshi Imai, Hitoshi Sakano

研究成果: Contribution to journalReview article査読

45 被引用数 (Scopus)

抄録

In the mouse olfactory system, there are ∼1000 types of odorant receptors (ORs), which perform multiple functions in olfactory sensory neurons (OSNs). In addition to detecting odors, the functional OR protein ensures the singular gene choice of the OR by negative-feedback regulation. ORs also direct the axonal projection of OSNs both globally and locally by modulating the transcriptional levels of axon-guidance and axon-sorting molecules. In these latter processes, the second messenger, cAMP, plays differential roles in the fasciculation and targeting of axons. In this review, we will discuss how ORs differentially regulate intracellular signals for distinct functions.

本文言語英語
ページ(範囲)251-260
ページ数10
ジャーナルCurrent Opinion in Neurobiology
18
3
DOI
出版ステータス出版済み - 6 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

フィンガープリント

「Odorant receptor-mediated signaling in the mouse」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル