Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles

Chalermchai Khemtong, Chase W. Kessinger, Osamu Togao, Jimin Ren, Masaya Takahashi, A. Dean Sherry, Jinming Gao

研究成果: 著書/レポートタイプへの貢献会議での発言

3 引用 (Scopus)

抄録

An off-resonance saturation (ORS) method was used for magnetic resonance imaging of superparamagnetic polymeric micelles (SPPM). SPPM was produced by encapsulating a cluster of magnetite nanoparticles (9.9±0.4 nm in diameter) in poly(ethylene glycol)-b-poly(D,L-lactide) (PEGPLA) copolymer micelles (micelle diameter: 60±9 nm). In ORS MRI, a selective radiofrequency (RF) pulse was applied at an off-resonance position (0-50 ppm) from the bulk water signal, and the SPPM particles were visualized by the contrast on a division image constructed from two images acquired with and without pre-saturation. Here, the effects of saturation offset frequencies, saturation durations, and RF powers on ORS contrasts were investigated as these parameters are critical for optimization of ORS MRI for in vivo imaging applications. The ability to turn "ON" and "OFF" ORS contrast of SPPM solutions permits for an accurate image subtraction and a contrast enhancement to visualize SPPM probes for in vivo imaging of cancer.

元の言語英語
ホスト出版物のタイトルProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ホスト出版物のサブタイトルEngineering the Future of Biomedicine, EMBC 2009
出版者IEEE Computer Society
ページ4095-4097
ページ数3
ISBN(印刷物)9781424432967
DOI
出版物ステータス出版済み - 1 1 2009
外部発表Yes
イベント31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, 米国
継続期間: 9 2 20099 6 2009

出版物シリーズ

名前Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

その他

その他31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
米国
Minneapolis, MN
期間9/2/099/6/09

Fingerprint

Micelles
Magnetic resonance
Magnetic Resonance Imaging
Imaging techniques
Magnetic resonance imaging
Magnetite Nanoparticles
Magnetite nanoparticles
Ethylene Glycol
Particles (particulate matter)
Polyethylene glycols
Copolymers
Water
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

これを引用

Khemtong, C., Kessinger, C. W., Togao, O., Ren, J., Takahashi, M., Sherry, A. D., & Gao, J. (2009). Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. : Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 4095-4097). [5334550] (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334550

Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. / Khemtong, Chalermchai; Kessinger, Chase W.; Togao, Osamu; Ren, Jimin; Takahashi, Masaya; Sherry, A. Dean; Gao, Jinming.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 4095-4097 5334550 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

研究成果: 著書/レポートタイプへの貢献会議での発言

Khemtong, C, Kessinger, CW, Togao, O, Ren, J, Takahashi, M, Sherry, AD & Gao, J 2009, Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. : Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5334550, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, IEEE Computer Society, pp. 4095-4097, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, 米国, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334550
Khemtong C, Kessinger CW, Togao O, Ren J, Takahashi M, Sherry AD その他. Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. : Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 4095-4097. 5334550. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). https://doi.org/10.1109/IEMBS.2009.5334550
Khemtong, Chalermchai ; Kessinger, Chase W. ; Togao, Osamu ; Ren, Jimin ; Takahashi, Masaya ; Sherry, A. Dean ; Gao, Jinming. / Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 4095-4097 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).
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