Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption

Kunihiko Sakumi, Yohei Tominaga, Masato Furuichi, Ping Xu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Yusaku Nakabeppu

研究成果: ジャーナルへの寄稿記事

169 引用 (Scopus)

抄録

Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice ∼1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mthl gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.

元の言語英語
ページ(範囲)902-905
ページ数4
ジャーナルCancer Research
63
発行部数5
出版物ステータス出版済み - 3 1 2003

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Knockout Mice
Carcinogenesis
Lung
Genes
Adenoma
Neoplasms
Parturition
Genome
Carcinoma
DNA
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. / Sakumi, Kunihiko; Tominaga, Yohei; Furuichi, Masato; Xu, Ping; Tsuzuki, Teruhisa; Sekiguchi, Mutsuo; Nakabeppu, Yusaku.

:: Cancer Research, 巻 63, 番号 5, 01.03.2003, p. 902-905.

研究成果: ジャーナルへの寄稿記事

Sakumi, Kunihiko ; Tominaga, Yohei ; Furuichi, Masato ; Xu, Ping ; Tsuzuki, Teruhisa ; Sekiguchi, Mutsuo ; Nakabeppu, Yusaku. / Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. :: Cancer Research. 2003 ; 巻 63, 番号 5. pp. 902-905.
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