Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition

Anne Sophie Champy-Tixier, Anne Claire Mitaine-Offer, Feliciana Real Fernández, Tomofumi Miyamoto, Chiaki Tanaka, Anna Maria Papini, Marie Aleth Lacaille-Dubois

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

Three triterpene glycosides were isolated from the roots of Weigela florida “rumba” (Bunge) A. DC.: two previously undescribed 3-O-β-D-xylopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (1) and 3-O-β-D-xylopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (2), and one isolated for the first time from a natural source 3-O-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid (3). Their structures were elucidated mainly by 2D NMR spectroscopic analysis (COSY, TOCSY, NOESY, HSQC, HMBC) and mass spectrometry. Compounds 2 and 3 were further evaluated as antigens in enzyme-linked immunosorbent assay (ELISA) to recognize IgM antibodies in multiple sclerosis (MS) patients’ sera.

本文言語英語
ページ(範囲)198-203
ページ数6
ジャーナルFitoterapia
128
DOI
出版ステータス出版済み - 7 2018

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬

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