Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans

Koji Yamada, Takaaki Hirotsu, Masahiro Matsuki, Rebecca A. Butcher, Masahiro Tomioka, Takeshi Ishihara, Jon Clardy, Hirofumi Kunitomo, Yuichi Iino

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Population density - dependent dispersal is a well-characterized strategy of animal behavior in which dispersal rate increases when population density is higher. Caenorhabditis elegans shows positive chemotaxis to a set of odorants, but the chemotaxis switches from attraction to dispersal after prolonged exposure to the odorants. We show here that this plasticity of olfactory behavior is dependent on population density and that this regulation is mediated by pheromonal signaling. We show that a peptide, suppressor of NEP-2 (SNET-1), negatively regulates olfactory plasticity and that its expression is down-regulated by the pheromone. NEP-2, a homolog of the extracellular peptidase neprilysin, antagonizes SNET-1, and this function is essential for olfactory plasticity. These results suggest that population density information is transmitted through the external pheromone and endogenous peptide signaling to modulate chemotactic behavior.

元の言語英語
ページ(範囲)1647-1650
ページ数4
ジャーナルScience
329
発行部数5999
DOI
出版物ステータス出版済み - 9 24 2010

All Science Journal Classification (ASJC) codes

  • General

フィンガープリント Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Yamada, K., Hirotsu, T., Matsuki, M., Butcher, R. A., Tomioka, M., Ishihara, T., Clardy, J., Kunitomo, H., & Iino, Y. (2010). Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science, 329(5999), 1647-1650. https://doi.org/10.1126/science.1192020