Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse

Akio Tsuboi, Takaaki Miyazaki, Takeshi Imai, Hitoshi Sakano

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

抄録

Vertebrate odorant receptor (OR) genes are divided phylogenetically into two distinct classes: the fish-like class I and the terrestrial-specific class II. In the present study, we systematically analysed mouse class I OR genes (42 subfamilies) to elucidate the expression profiles in the olfactory epithelium (OE) and the projection sites of their olfactory sensory neurons (OSNs) in the olfactory bulb (OB). In situ hybridization (ISH) revealed that most class I OR genes (36 subfamilies) were expressed in the dorso-medial zone (zone 1) of the OE. Furthermore, there appeared to be no significant differences in the distributions of OSNs expressing class I genes within zone 1. These results indicate that there is a clear boundary between zone 1 and non-zone 1 areas in the OE. Some class I ORs are known to possess ligand specificity for aliphatic acids, aldehydes and alcohols. Our ISH analysis has revealed that OSNs expressing the class I ORs in zone 1 tend to converge their axons on a cluster of glomeruli in an antero-dorsal domain that is assumed to be involved in responses to the aliphatic compounds on the OB.

元の言語英語
ページ(範囲)1436-1444
ページ数9
ジャーナルEuropean Journal of Neuroscience
23
発行部数6
DOI
出版物ステータス出版済み - 3 2006
外部発表Yes

Fingerprint

Odorant Receptors
Olfactory Receptor Neurons
Olfactory Mucosa
Olfactory Bulb
Axons
In Situ Hybridization
Genes
MHC Class I Genes
Aldehydes
Vertebrates
Fishes
Fatty Acids
Alcohols
Ligands

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse. / Tsuboi, Akio; Miyazaki, Takaaki; Imai, Takeshi; Sakano, Hitoshi.

:: European Journal of Neuroscience, 巻 23, 番号 6, 03.2006, p. 1436-1444.

研究成果: ジャーナルへの寄稿記事

@article{216081b2226e4d78aab915873599752b,
title = "Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse",
abstract = "Vertebrate odorant receptor (OR) genes are divided phylogenetically into two distinct classes: the fish-like class I and the terrestrial-specific class II. In the present study, we systematically analysed mouse class I OR genes (42 subfamilies) to elucidate the expression profiles in the olfactory epithelium (OE) and the projection sites of their olfactory sensory neurons (OSNs) in the olfactory bulb (OB). In situ hybridization (ISH) revealed that most class I OR genes (36 subfamilies) were expressed in the dorso-medial zone (zone 1) of the OE. Furthermore, there appeared to be no significant differences in the distributions of OSNs expressing class I genes within zone 1. These results indicate that there is a clear boundary between zone 1 and non-zone 1 areas in the OE. Some class I ORs are known to possess ligand specificity for aliphatic acids, aldehydes and alcohols. Our ISH analysis has revealed that OSNs expressing the class I ORs in zone 1 tend to converge their axons on a cluster of glomeruli in an antero-dorsal domain that is assumed to be involved in responses to the aliphatic compounds on the OB.",
author = "Akio Tsuboi and Takaaki Miyazaki and Takeshi Imai and Hitoshi Sakano",
year = "2006",
month = "3",
doi = "10.1111/j.1460-9568.2006.04675.x",
language = "English",
volume = "23",
pages = "1436--1444",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse

AU - Tsuboi, Akio

AU - Miyazaki, Takaaki

AU - Imai, Takeshi

AU - Sakano, Hitoshi

PY - 2006/3

Y1 - 2006/3

N2 - Vertebrate odorant receptor (OR) genes are divided phylogenetically into two distinct classes: the fish-like class I and the terrestrial-specific class II. In the present study, we systematically analysed mouse class I OR genes (42 subfamilies) to elucidate the expression profiles in the olfactory epithelium (OE) and the projection sites of their olfactory sensory neurons (OSNs) in the olfactory bulb (OB). In situ hybridization (ISH) revealed that most class I OR genes (36 subfamilies) were expressed in the dorso-medial zone (zone 1) of the OE. Furthermore, there appeared to be no significant differences in the distributions of OSNs expressing class I genes within zone 1. These results indicate that there is a clear boundary between zone 1 and non-zone 1 areas in the OE. Some class I ORs are known to possess ligand specificity for aliphatic acids, aldehydes and alcohols. Our ISH analysis has revealed that OSNs expressing the class I ORs in zone 1 tend to converge their axons on a cluster of glomeruli in an antero-dorsal domain that is assumed to be involved in responses to the aliphatic compounds on the OB.

AB - Vertebrate odorant receptor (OR) genes are divided phylogenetically into two distinct classes: the fish-like class I and the terrestrial-specific class II. In the present study, we systematically analysed mouse class I OR genes (42 subfamilies) to elucidate the expression profiles in the olfactory epithelium (OE) and the projection sites of their olfactory sensory neurons (OSNs) in the olfactory bulb (OB). In situ hybridization (ISH) revealed that most class I OR genes (36 subfamilies) were expressed in the dorso-medial zone (zone 1) of the OE. Furthermore, there appeared to be no significant differences in the distributions of OSNs expressing class I genes within zone 1. These results indicate that there is a clear boundary between zone 1 and non-zone 1 areas in the OE. Some class I ORs are known to possess ligand specificity for aliphatic acids, aldehydes and alcohols. Our ISH analysis has revealed that OSNs expressing the class I ORs in zone 1 tend to converge their axons on a cluster of glomeruli in an antero-dorsal domain that is assumed to be involved in responses to the aliphatic compounds on the OB.

UR - http://www.scopus.com/inward/record.url?scp=33645099735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645099735&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2006.04675.x

DO - 10.1111/j.1460-9568.2006.04675.x

M3 - Article

C2 - 16553607

AN - SCOPUS:33645099735

VL - 23

SP - 1436

EP - 1444

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 6

ER -