Oligonucleotides as a tool for intracellular DDS

研究成果: ジャーナルへの寄稿記事

抜粋

Oligonucleotides attaching a reactive molecule may cause irreversible change to the target sequence at the reactive site. Inhibition of transcription, site-directed mutagenesis (or site-directed manipulation of genes) at the specific site has been proposed as a new tool of biotechnology with the use of a triplex-forming oligonucleotide. Thus, the oligonucleotides are regarded as a tool for intracellular DOS of useful reactive molecules. This review deals with development of a new alkylating group with high selectivity toward cytosine as well as new non-natural base analogs for the formation of stable non-natural triplexes.

元の言語英語
ページ(範囲)478-485
ページ数8
ジャーナルDrug Delivery System
17
発行部数6
DOI
出版物ステータス出版済み - 1 1 2002

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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