TY - GEN
T1 - On-Chip Cell Gym
AU - Horade, Mitsuhiro
AU - Tsai, Chia Hung Dylan
AU - Ito, Hiroaki
AU - Higashino, Nobuya
AU - Akai, Takayuki
AU - Yokoyama, Utako
AU - Ishikawa, Yoshihiro
AU - Sakuma, Shinya
AU - Arai, Fumihito
AU - Kaneko, Makoto
N1 - Publisher Copyright:
© 2017 IEEE.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/2/23
Y1 - 2017/2/23
N2 - A novel microfluidic system for applying cyclic pressure to cells during incubation is developed and tested in this work. The cyclic pressure generates stress stimulus to the cells, and is named 'Cell Exercise' in this work. The goal of this paper is to design an 'On-Chip Cell Gym' where we can observe what happens during the cell exercise in real-time. We design the cell gym on a PDMS chip composed of two parallel chamber arrays, so that we can directly observe the difference with and without Cell Exercise. Cells in one group of chamber is cultured under cell exercise mode and the other one is under none cell exercise mode. Dramatic growth of cell stress fibers is observed in the group of cell exercise with respect to the group without any exercise.
AB - A novel microfluidic system for applying cyclic pressure to cells during incubation is developed and tested in this work. The cyclic pressure generates stress stimulus to the cells, and is named 'Cell Exercise' in this work. The goal of this paper is to design an 'On-Chip Cell Gym' where we can observe what happens during the cell exercise in real-time. We design the cell gym on a PDMS chip composed of two parallel chamber arrays, so that we can directly observe the difference with and without Cell Exercise. Cells in one group of chamber is cultured under cell exercise mode and the other one is under none cell exercise mode. Dramatic growth of cell stress fibers is observed in the group of cell exercise with respect to the group without any exercise.
UR - http://www.scopus.com/inward/record.url?scp=85015810291&partnerID=8YFLogxK
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U2 - 10.1109/MEMSYS.2017.7863479
DO - 10.1109/MEMSYS.2017.7863479
M3 - Conference contribution
AN - SCOPUS:85015810291
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 603
EP - 604
BT - 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
Y2 - 22 January 2017 through 26 January 2017
ER -