TY - JOUR
T1 - On-chip measurement of cellular mechanical properties using moiré fringe
AU - Sugiura, Hirotaka
AU - Sakuma, Shinya
AU - Kaneko, Makoto
AU - Arai, Fumihito
N1 - Publisher Copyright:
© 2015 IEEE.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/6/29
Y1 - 2015/6/29
N2 - This paper proposes the method for mechanical characterization of floating cells on a microfluidic chip. We measured the reactive force of cells on the chip by applying mechanical deformation to the cells. Particularly we focused on the method to improve the sensing resolution of the probe position by using the phase detection of moiré fringe. This method realized approximately ten times higher resolution compared to the previous method. The detailed data suggest some unique characteristics of cells. We discussed the phenomenon seen on the data with a mechanical model, which is based on Heltzian contact theory in the light of stiff nucleus.
AB - This paper proposes the method for mechanical characterization of floating cells on a microfluidic chip. We measured the reactive force of cells on the chip by applying mechanical deformation to the cells. Particularly we focused on the method to improve the sensing resolution of the probe position by using the phase detection of moiré fringe. This method realized approximately ten times higher resolution compared to the previous method. The detailed data suggest some unique characteristics of cells. We discussed the phenomenon seen on the data with a mechanical model, which is based on Heltzian contact theory in the light of stiff nucleus.
UR - http://www.scopus.com/inward/record.url?scp=84938281478&partnerID=8YFLogxK
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U2 - 10.1109/ICRA.2015.7139685
DO - 10.1109/ICRA.2015.7139685
M3 - Conference article
AN - SCOPUS:84938281478
VL - 2015-June
SP - 3513
EP - 3518
JO - Proceedings - IEEE International Conference on Robotics and Automation
JF - Proceedings - IEEE International Conference on Robotics and Automation
SN - 1050-4729
IS - June
M1 - 7139685
T2 - 2015 IEEE International Conference on Robotics and Automation, ICRA 2015
Y2 - 26 May 2015 through 30 May 2015
ER -