Open-loop, clockwise QT-RR hysteresis immediately before the onset of torsades de pointes in type 2 long QT syndrome

Gen Nakaji, Masahiko Fujiwara, Mitsuhiro Fukata, Shioto Yasuda, Keita Odashiro, Toru Maruyama, Koichi Akashi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抜粋

Delay of QT interval adaptation to sudden heart rate change causes hysteresis in dynamic QT-RR relationship. We analyzed QT-RR plotting during and after exercise in a patient with genetically identified type 2 long QT syndrome before and after starting oral propranolol. Blunted QT shortening by exercise and augmented postexercise QT prolongation resulted in an open-loop, clockwise QT-RR hysteresis immediately before the onset of torsades de pointes before propranolol. However, this hysteresis was eliminated by propranolol. QT-RR analysis provided insight into the mechanisms of the onset of torsades de pointes at least in this case of type 2 long QT syndrome.

元の言語英語
ページ(範囲)261-263
ページ数3
ジャーナルJournal of Electrocardiology
43
発行部数3
DOI
出版物ステータス出版済み - 5 1 2010

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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