Opposite effects of alternative TZF spliced variants on androgen receptor

Rong Hua Tao, Hisaya Kawate, Keizo Ohnaka, Masamichi Ishizuka, Hiromi Hagiwara, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR). In the present study, we further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR. Deletion analysis of TZF-L revealed that its N-terminus, which almost corresponded to that of TZF, but not its C-terminus was able to interact with AR. Additional analysis suggested that TZF and TZF-L were able to form both homodimers and heterodimers. TZF-L inhibited the homodimer formation of TZF and the intranuclear dot formation of TZF. We propose that in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively.

本文言語英語
ページ(範囲)515-521
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
341
2
DOI
出版ステータス出版済み - 3月 10 2006

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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