Optical microscopic observation of fluorescence enhanced by grating-coupled surface plasmon resonance

Keiko Tawa, Hironobu Hori, Kenji Kintaka, Kazuyuki Kiyosue, Yoshiro Tatsu, Junji Nishii

研究成果: Contribution to journalArticle査読

82 被引用数 (Scopus)

抄録

On the substrate carrying a sub-wavelength grating covered with a thin metal layer, a fluorescent dye-labeled cell was observed by fluorescence microscope. The fluorescence intensity was more than 20 times greater than that on an optically flat glass substrate. Such a great fluorescence enhancement from labeled cells bound to the grating substrate was due to the excitation by grating coupled surface plasmon resonance. The application of a grating substrate to two-dimensional detection and fluorescence microscopy appears to offer a promising method of taking highly sensitive fluorescence images.

本文言語英語
ページ(範囲)9781-9790
ページ数10
ジャーナルOptics Express
16
13
DOI
出版ステータス出版済み - 6 23 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 原子分子物理学および光学

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