TY - JOUR
T1 - Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice
AU - Yoshioka, Yasuko
AU - Kudo, Satsuki
AU - Nishimura, Hitoshi
AU - Yajima, Toshiki
AU - Kishihara, Kenji
AU - Saito, Kimika
AU - Suzuki, Tatsuo
AU - Suzuki, Yumiko
AU - Kuroiwa, Shinsuke
AU - Yoshikai, Yasunobu
PY - 2005/3
Y1 - 2005/3
N2 - Th1 stimulus for Th2-skewed immune response during infancy is important for reduction of incidence of allergic diseases. We examined effects of oral administration of bovine colostrum on local immunity in intestine in adult mice. C57BL/6 mice were orally given bovine colostrum or control milk for 1, 3 or 6 months and intestinal microflora, fecal IgA, and lymphocyte population of gut-associated lymphoid tissues and their abilities of cytokine production were examined. Although the cell populations of intestinal intraepithelial lymphocytes (i-IEL) were not remarkably changed, the T cells in i-IEL were polarized to Th1 type after oral administration of bovine colostrum. Intestinal microflora and IgA levels in feces were not changed by oral administration of bovine colostrum. These results suggest that colostrum stimulates directly to i-IEL to polarize Th1 type, which may protect from infectious diseases and allergic diseases mediated by Th2 type responses.
AB - Th1 stimulus for Th2-skewed immune response during infancy is important for reduction of incidence of allergic diseases. We examined effects of oral administration of bovine colostrum on local immunity in intestine in adult mice. C57BL/6 mice were orally given bovine colostrum or control milk for 1, 3 or 6 months and intestinal microflora, fecal IgA, and lymphocyte population of gut-associated lymphoid tissues and their abilities of cytokine production were examined. Although the cell populations of intestinal intraepithelial lymphocytes (i-IEL) were not remarkably changed, the T cells in i-IEL were polarized to Th1 type after oral administration of bovine colostrum. Intestinal microflora and IgA levels in feces were not changed by oral administration of bovine colostrum. These results suggest that colostrum stimulates directly to i-IEL to polarize Th1 type, which may protect from infectious diseases and allergic diseases mediated by Th2 type responses.
UR - http://www.scopus.com/inward/record.url?scp=20144379513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20144379513&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2004.11.005
DO - 10.1016/j.intimp.2004.11.005
M3 - Article
C2 - 15683853
AN - SCOPUS:20144379513
VL - 5
SP - 581
EP - 590
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 3
ER -