Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats

Shozo Tomonaga, Toru Hayakawa, Haruka Yamane, Hirohiko Maemura, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

Carnosine (β-alanyl-L-histidine) and its derivative anserine (β-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whether single oral administration of CBEX (20 ml/kg) affects brain dipeptide and free amino acid concentrations in male Wistar rats. CBEX significantly and time-dependently increased carnosine and anserine levels in the plasma (at 120 min after injection, increase rates were 2976 and 4142%, respectively), hippocampus (64 and 78%), and hypothalamus (188 and 120%), but not in cerebral cortex. Significant and time-dependent increases in citrulline in the hippocampus (49%) and hypothalamus (41%) demonstrated generation of nitric oxide due to the increased carnosine and/or anserine levels in these brain regions. These findings suggest that CBEX modifies brain functions by increasing levels of these dipeptides.

本文言語英語
ページ(範囲)181-186
ページ数6
ジャーナルNutritional Neuroscience
10
3-4
DOI
出版ステータス出版済み - 6 1 2007

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 神経科学(全般)
  • 栄養および糖尿病

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