Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Objective: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. Subjects and Methods: The subjects (410; 181 males and 229 females) were 75–99 years of age; those under prior antibiotic use were excluded. Fungal populations in the saliva were evaluated by PCR-based molecular techniques. Body mass index (BMI), smoking habits, and oral health conditions were examined. Results: Salivary fungal amounts exceeded 104 CFU/ml in 63 (15.4%) of 410 subjects. Candida albicans was most frequently detected (98.4%), followed by Candida glabrata (54.0%), and Candida dubliniensis (38.1%) in those subjects with fungi at 104 CFU/ml or over. Fungi at 104 CFU/ml or over in the presence of C. glabrata or C. dubliniensis was significantly associated with low BMI. Conclusions: Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.

元の言語英語
ページ(範囲)973-982
ページ数10
ジャーナルOral Diseases
23
発行部数7
DOI
出版物ステータス出版済み - 10 1 2017

Fingerprint

Independent Living
Oral Health
Body Mass Index
Candida albicans
Fungi
Dysbiosis
Population
Anti-Bacterial Agents
Candida glabrata
Mycoses
Candidiasis
Candida
Saliva
Health Status
Habits
Smoking
Polymerase Chain Reaction
Mycobiome

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

これを引用

Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions. / Zakaria, M. N.; Furuta, Michiko; Takeshita, Toru; Shibata, Yukie; Sundari, R.; Eshima, N.; Ninomiya, Toshiharu; Yamashita, Yoshihisa.

:: Oral Diseases, 巻 23, 番号 7, 01.10.2017, p. 973-982.

研究成果: ジャーナルへの寄稿記事

@article{0cc2aef178cb47a3bc1e011a600b241d,
title = "Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions",
abstract = "Objective: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. Subjects and Methods: The subjects (410; 181 males and 229 females) were 75–99 years of age; those under prior antibiotic use were excluded. Fungal populations in the saliva were evaluated by PCR-based molecular techniques. Body mass index (BMI), smoking habits, and oral health conditions were examined. Results: Salivary fungal amounts exceeded 104 CFU/ml in 63 (15.4{\%}) of 410 subjects. Candida albicans was most frequently detected (98.4{\%}), followed by Candida glabrata (54.0{\%}), and Candida dubliniensis (38.1{\%}) in those subjects with fungi at 104 CFU/ml or over. Fungi at 104 CFU/ml or over in the presence of C. glabrata or C. dubliniensis was significantly associated with low BMI. Conclusions: Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.",
author = "Zakaria, {M. N.} and Michiko Furuta and Toru Takeshita and Yukie Shibata and R. Sundari and N. Eshima and Toshiharu Ninomiya and Yoshihisa Yamashita",
year = "2017",
month = "10",
day = "1",
doi = "10.1111/odi.12682",
language = "English",
volume = "23",
pages = "973--982",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions

AU - Zakaria, M. N.

AU - Furuta, Michiko

AU - Takeshita, Toru

AU - Shibata, Yukie

AU - Sundari, R.

AU - Eshima, N.

AU - Ninomiya, Toshiharu

AU - Yamashita, Yoshihisa

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objective: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. Subjects and Methods: The subjects (410; 181 males and 229 females) were 75–99 years of age; those under prior antibiotic use were excluded. Fungal populations in the saliva were evaluated by PCR-based molecular techniques. Body mass index (BMI), smoking habits, and oral health conditions were examined. Results: Salivary fungal amounts exceeded 104 CFU/ml in 63 (15.4%) of 410 subjects. Candida albicans was most frequently detected (98.4%), followed by Candida glabrata (54.0%), and Candida dubliniensis (38.1%) in those subjects with fungi at 104 CFU/ml or over. Fungi at 104 CFU/ml or over in the presence of C. glabrata or C. dubliniensis was significantly associated with low BMI. Conclusions: Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.

AB - Objective: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. Subjects and Methods: The subjects (410; 181 males and 229 females) were 75–99 years of age; those under prior antibiotic use were excluded. Fungal populations in the saliva were evaluated by PCR-based molecular techniques. Body mass index (BMI), smoking habits, and oral health conditions were examined. Results: Salivary fungal amounts exceeded 104 CFU/ml in 63 (15.4%) of 410 subjects. Candida albicans was most frequently detected (98.4%), followed by Candida glabrata (54.0%), and Candida dubliniensis (38.1%) in those subjects with fungi at 104 CFU/ml or over. Fungi at 104 CFU/ml or over in the presence of C. glabrata or C. dubliniensis was significantly associated with low BMI. Conclusions: Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.

UR - http://www.scopus.com/inward/record.url?scp=85020472347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020472347&partnerID=8YFLogxK

U2 - 10.1111/odi.12682

DO - 10.1111/odi.12682

M3 - Article

C2 - 28419681

AN - SCOPUS:85020472347

VL - 23

SP - 973

EP - 982

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 7

ER -