Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms

Takeyuki Tada, Masashi Shin, Hidefumi Fukushima, Koji Okabe, Satoru Ozeki, Masato Okamoto, Eijiro Jimi

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

Oral squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and bone invasion is a common clinical problem. Recent studies have revealed that bone resorption by osteoclasts is an important step in the progress of bone invasion by oral SCCs. We previously reported that oral SCC cells induce osteoclastogenesis by suppressing osteoprotegerin (OPG) in host cells. In the present study, we examined the effects of oral SCCs on osteoclast function. Both BHY cells, a human oral SCC cell line, and its conditioned medium (BHY-CM) stimulated osteoclast survival by suppressing Bim, a pro-apoptotic protein, depending on extracellular signal-regulated kinase (ERK) and multinucleation. Adding BHY cells but not BHY-CM induced pit-forming activity by osteoclasts and adding OPG abrogated the activity. Thus, oral SCC cells regulate not only osteoclastogenesis but also its function.

元の言語英語
ページ(範囲)126-131
ページ数6
ジャーナルCancer Letters
274
発行部数1
DOI
出版物ステータス出版済み - 2 8 2009
外部発表Yes

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Osteoclasts
Squamous Cell Carcinoma
Osteoprotegerin
Osteogenesis
Bone and Bones
Apoptosis Regulatory Proteins
Extracellular Signal-Regulated MAP Kinases
Bone Resorption
Conditioned Culture Medium
Cell Line

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms. / Tada, Takeyuki; Shin, Masashi; Fukushima, Hidefumi; Okabe, Koji; Ozeki, Satoru; Okamoto, Masato; Jimi, Eijiro.

:: Cancer Letters, 巻 274, 番号 1, 08.02.2009, p. 126-131.

研究成果: ジャーナルへの寄稿記事

Tada, Takeyuki ; Shin, Masashi ; Fukushima, Hidefumi ; Okabe, Koji ; Ozeki, Satoru ; Okamoto, Masato ; Jimi, Eijiro. / Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms. :: Cancer Letters. 2009 ; 巻 274, 番号 1. pp. 126-131.
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AU - Ozeki, Satoru

AU - Okamoto, Masato

AU - Jimi, Eijiro

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