Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens

Masahiko Annaka, Kell Mortensen, Toyoaki Matsuura, Masaya Ito, Katsunori Nochioka, Nahoko Ogata

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

We focus on the development of a novel injectable accommodative lens for intraocular applications, which is based on a thermosensitive hydrophobically modified poly(ethylene glycol) (HM-PEG) containing hydrophilized silica nanoparticles. We distinguished macroscopically, with changes in the temperature or concentration, two regions in the phase diagram for aqueous solution of HM-PEG: transparent sol and transparent gel. These changes occurred reversibly, without hysteresis, when the temperature was decreased. The temperature and concentration regime in which the gel formed are reduced by adding silica nanoparticles into the gel matrix. Small-angle neutron scattering measurements for nanocomposite gels provide good proof of a gel phase where the high shear-modulus is gained by a high inter-micellar correlation originating in the crystalline order. Under the condition of uniform distribution of silica nanoparticles with small size (2-5 nm) in the gel matrix, an increase in the refractive index up to 0.0667 was obtained for the nanocomposite gel compared with the native gel matrix without an increase in turbidity. This composite system could be formulated to match the modulus and the refractive index of the natural lens (∼1.411), and was easily extruded through a narrow-gauge needle. Rapid endocapsular gelation yielded an optically clear gel within the lens capsular bag. This technique enables us to validate methods to determine the biomechanics of the lens and its role in accommodation. The modification of the mechanical response and stability of the HM-PEG network by addition of silica nanoparticles was also investigated in detail.

元の言語英語
ページ(範囲)7185-7196
ページ数12
ジャーナルSoft Matter
8
発行部数27
DOI
出版物ステータス出版済み - 7 21 2012

Fingerprint

Intraocular lenses
gelation
Biocompatible Materials
Gelation
Nanocomposites
nanocomposites
Gels
lenses
gels
Silicon Dioxide
Lenses
Polyethylene glycols
Nanoparticles
silicon dioxide
glycols
nanoparticles
ethylene
Refractive index
matrices
refractivity

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

これを引用

Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens. / Annaka, Masahiko; Mortensen, Kell; Matsuura, Toyoaki; Ito, Masaya; Nochioka, Katsunori; Ogata, Nahoko.

:: Soft Matter, 巻 8, 番号 27, 21.07.2012, p. 7185-7196.

研究成果: ジャーナルへの寄稿記事

Annaka, Masahiko ; Mortensen, Kell ; Matsuura, Toyoaki ; Ito, Masaya ; Nochioka, Katsunori ; Ogata, Nahoko. / Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens. :: Soft Matter. 2012 ; 巻 8, 番号 27. pp. 7185-7196.
@article{2d261bd237174e48b5555b3e0daf9b55,
title = "Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens",
abstract = "We focus on the development of a novel injectable accommodative lens for intraocular applications, which is based on a thermosensitive hydrophobically modified poly(ethylene glycol) (HM-PEG) containing hydrophilized silica nanoparticles. We distinguished macroscopically, with changes in the temperature or concentration, two regions in the phase diagram for aqueous solution of HM-PEG: transparent sol and transparent gel. These changes occurred reversibly, without hysteresis, when the temperature was decreased. The temperature and concentration regime in which the gel formed are reduced by adding silica nanoparticles into the gel matrix. Small-angle neutron scattering measurements for nanocomposite gels provide good proof of a gel phase where the high shear-modulus is gained by a high inter-micellar correlation originating in the crystalline order. Under the condition of uniform distribution of silica nanoparticles with small size (2-5 nm) in the gel matrix, an increase in the refractive index up to 0.0667 was obtained for the nanocomposite gel compared with the native gel matrix without an increase in turbidity. This composite system could be formulated to match the modulus and the refractive index of the natural lens (∼1.411), and was easily extruded through a narrow-gauge needle. Rapid endocapsular gelation yielded an optically clear gel within the lens capsular bag. This technique enables us to validate methods to determine the biomechanics of the lens and its role in accommodation. The modification of the mechanical response and stability of the HM-PEG network by addition of silica nanoparticles was also investigated in detail.",
author = "Masahiko Annaka and Kell Mortensen and Toyoaki Matsuura and Masaya Ito and Katsunori Nochioka and Nahoko Ogata",
year = "2012",
month = "7",
day = "21",
doi = "10.1039/c2sm25534k",
language = "English",
volume = "8",
pages = "7185--7196",
journal = "Soft Matter",
issn = "1744-683X",
publisher = "Royal Society of Chemistry",
number = "27",

}

TY - JOUR

T1 - Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens

AU - Annaka, Masahiko

AU - Mortensen, Kell

AU - Matsuura, Toyoaki

AU - Ito, Masaya

AU - Nochioka, Katsunori

AU - Ogata, Nahoko

PY - 2012/7/21

Y1 - 2012/7/21

N2 - We focus on the development of a novel injectable accommodative lens for intraocular applications, which is based on a thermosensitive hydrophobically modified poly(ethylene glycol) (HM-PEG) containing hydrophilized silica nanoparticles. We distinguished macroscopically, with changes in the temperature or concentration, two regions in the phase diagram for aqueous solution of HM-PEG: transparent sol and transparent gel. These changes occurred reversibly, without hysteresis, when the temperature was decreased. The temperature and concentration regime in which the gel formed are reduced by adding silica nanoparticles into the gel matrix. Small-angle neutron scattering measurements for nanocomposite gels provide good proof of a gel phase where the high shear-modulus is gained by a high inter-micellar correlation originating in the crystalline order. Under the condition of uniform distribution of silica nanoparticles with small size (2-5 nm) in the gel matrix, an increase in the refractive index up to 0.0667 was obtained for the nanocomposite gel compared with the native gel matrix without an increase in turbidity. This composite system could be formulated to match the modulus and the refractive index of the natural lens (∼1.411), and was easily extruded through a narrow-gauge needle. Rapid endocapsular gelation yielded an optically clear gel within the lens capsular bag. This technique enables us to validate methods to determine the biomechanics of the lens and its role in accommodation. The modification of the mechanical response and stability of the HM-PEG network by addition of silica nanoparticles was also investigated in detail.

AB - We focus on the development of a novel injectable accommodative lens for intraocular applications, which is based on a thermosensitive hydrophobically modified poly(ethylene glycol) (HM-PEG) containing hydrophilized silica nanoparticles. We distinguished macroscopically, with changes in the temperature or concentration, two regions in the phase diagram for aqueous solution of HM-PEG: transparent sol and transparent gel. These changes occurred reversibly, without hysteresis, when the temperature was decreased. The temperature and concentration regime in which the gel formed are reduced by adding silica nanoparticles into the gel matrix. Small-angle neutron scattering measurements for nanocomposite gels provide good proof of a gel phase where the high shear-modulus is gained by a high inter-micellar correlation originating in the crystalline order. Under the condition of uniform distribution of silica nanoparticles with small size (2-5 nm) in the gel matrix, an increase in the refractive index up to 0.0667 was obtained for the nanocomposite gel compared with the native gel matrix without an increase in turbidity. This composite system could be formulated to match the modulus and the refractive index of the natural lens (∼1.411), and was easily extruded through a narrow-gauge needle. Rapid endocapsular gelation yielded an optically clear gel within the lens capsular bag. This technique enables us to validate methods to determine the biomechanics of the lens and its role in accommodation. The modification of the mechanical response and stability of the HM-PEG network by addition of silica nanoparticles was also investigated in detail.

UR - http://www.scopus.com/inward/record.url?scp=84869598699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869598699&partnerID=8YFLogxK

U2 - 10.1039/c2sm25534k

DO - 10.1039/c2sm25534k

M3 - Article

AN - SCOPUS:84869598699

VL - 8

SP - 7185

EP - 7196

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 27

ER -