Osteocalcin and its endocrine functions

Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Masato Hirata

研究成果: ジャーナルへの寄稿評論記事

18 引用 (Scopus)

抄録

Bone has traditionally been regarded as a static structural organ that supports movement of the body and protects the internal organs. However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production and increasing energy expenditure and insulin sensitivity in target organs. Animal studies have shown that an increase in the circulating concentration of osteocalcin, including via exogenous application of the protein, prevents obesity and glucose intolerance. Moreover, a number of epidemiological analyses support the role of osteocalcin in the regulation of glucose and energy homeostasis in humans. Therefore, it has been suggested that osteocalcin could be a feasible preventive or therapeutic agent for metabolic disorders. In this review, we summarize the current knowledge regarding the endocrine functions of osteocalcin and its various modes of action.

元の言語英語
ページ(範囲)1-8
ページ数8
ジャーナルBiochemical Pharmacology
132
DOI
出版物ステータス出版済み - 5 15 2017

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Osteocalcin
Glucose
Energy Metabolism
Bone
Insulin
Bone and Bones
Glucose Intolerance
Osteoblasts
Insulin Resistance
Animals
Proteins
Homeostasis
Obesity
Hormones

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

これを引用

Osteocalcin and its endocrine functions. / Mizokami, Akiko; Kawakubo-Yasukochi, Tomoyo; Hirata, Masato.

:: Biochemical Pharmacology, 巻 132, 15.05.2017, p. 1-8.

研究成果: ジャーナルへの寄稿評論記事

Mizokami, Akiko ; Kawakubo-Yasukochi, Tomoyo ; Hirata, Masato. / Osteocalcin and its endocrine functions. :: Biochemical Pharmacology. 2017 ; 巻 132. pp. 1-8.
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