抄録
Bone has traditionally been regarded as a static structural organ that supports movement of the body and protects the internal organs. However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production and increasing energy expenditure and insulin sensitivity in target organs. Animal studies have shown that an increase in the circulating concentration of osteocalcin, including via exogenous application of the protein, prevents obesity and glucose intolerance. Moreover, a number of epidemiological analyses support the role of osteocalcin in the regulation of glucose and energy homeostasis in humans. Therefore, it has been suggested that osteocalcin could be a feasible preventive or therapeutic agent for metabolic disorders. In this review, we summarize the current knowledge regarding the endocrine functions of osteocalcin and its various modes of action.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1-8 |
| ページ数 | 8 |
| ジャーナル | Biochemical Pharmacology |
| 巻 | 132 |
| DOI | |
| 出版物ステータス | 出版済み - 5 15 2017 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Pharmacology
これを引用
Osteocalcin and its endocrine functions. / Mizokami, Akiko; Kawakubo-Yasukochi, Tomoyo; Hirata, Masato.
：: Biochemical Pharmacology, 巻 132, 15.05.2017, p. 1-8.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Osteocalcin and its endocrine functions
AU - Mizokami, Akiko
AU - Kawakubo-Yasukochi, Tomoyo
AU - Hirata, Masato
PY - 2017/5/15
Y1 - 2017/5/15
N2 - Bone has traditionally been regarded as a static structural organ that supports movement of the body and protects the internal organs. However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production and increasing energy expenditure and insulin sensitivity in target organs. Animal studies have shown that an increase in the circulating concentration of osteocalcin, including via exogenous application of the protein, prevents obesity and glucose intolerance. Moreover, a number of epidemiological analyses support the role of osteocalcin in the regulation of glucose and energy homeostasis in humans. Therefore, it has been suggested that osteocalcin could be a feasible preventive or therapeutic agent for metabolic disorders. In this review, we summarize the current knowledge regarding the endocrine functions of osteocalcin and its various modes of action.
AB - Bone has traditionally been regarded as a static structural organ that supports movement of the body and protects the internal organs. However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production and increasing energy expenditure and insulin sensitivity in target organs. Animal studies have shown that an increase in the circulating concentration of osteocalcin, including via exogenous application of the protein, prevents obesity and glucose intolerance. Moreover, a number of epidemiological analyses support the role of osteocalcin in the regulation of glucose and energy homeostasis in humans. Therefore, it has been suggested that osteocalcin could be a feasible preventive or therapeutic agent for metabolic disorders. In this review, we summarize the current knowledge regarding the endocrine functions of osteocalcin and its various modes of action.
UR - http://www.scopus.com/inward/record.url?scp=85013069682&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013069682&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2017.02.001
DO - 10.1016/j.bcp.2017.02.001
M3 - Review article
C2 - 28189726
AN - SCOPUS:85013069682
VL - 132
SP - 1
EP - 8
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
ER -