Osteoclastogenic activity during mandibular distraction osteogenesis

L. C. Wang, I. Takahashi, Y. Sasano, J. Sugawara, H. Mitani

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Mandibular distraction osteogenesis is a well-developed clinical modality for the treatment of craniofacial deformities and dental arch discrepancies, in combination with orthodontic treatment. However, in our previous study, orthodontic tooth movement into the distraction gap caused severe root resorption. The present study aimed to clarify the osteoclastogenic activity of cells in the distraction gap. We hypothesized that the gene expression of osteoclastogenic- and osteoclast-supporting molecules in osteoblasts and stromal cells would increase at distraction sites during the consolidation period. An animal model experiment involving rabbits was designed for mandibular distraction osteogenesis and subjected to in situ hybridization analysis. The number of osteoclasts was larger in the distraction gap during the early consolidation period than in normal controls, due to an increase of gene expression for osteoclastogenic cytokines in osteoblasts. It was concluded that osteoclastogenic and osteoclastic activities are stimulated at distraction sites during the early consolidation period.

本文言語英語
ページ(範囲)1010-1015
ページ数6
ジャーナルJournal of Dental Research
84
11
DOI
出版ステータス出版済み - 11 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 歯科学(全般)

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